Researchers suggest that increasing levels of FoxO proteins could be one way to prevent and treat osteoarthritis.
Researchers at The Scripps Research Institute (TSRI) in San Diego, CA, reveal that proteins called FoxO are key for joint health. By boosting the levels of these FoxO proteins, they believe that it might be possible to treat osteoarthritis, or even stop the disease from developing.
>Senior study author Dr. Martin Lotz — from the Department of Molecular Medicine at TSRI — and his team recently reported their results in the journal Science Translational Medicine.
Osteoarthritis, also referred to as degenerative joint disease, is estimated to affect more than 30 million adults in the United States, making it the most common type of arthritis.
The condition is characterized by a breakdown of cartilage, which is the tissue that cushions the joints of the bones. Osteoarthritis most commonly affects the knee, hip, and hand joints.
In a previous study, Dr. Lotz and team found that FoxO levels in joint cartilage are reduced. For this latest study, the researchers sought to find out more about how FoxO proteins affect joint health.